Biotin and derivatives
Medchemexpress LLC UV cleavable biotin-PEG2-azide | 1192802-98-4 | MFCD11845531 | 95.6% | C38H51N7O9S | 10MG
UV Cleavable Biotin-PEG2-Azide is a photocleavable biotinylation reagent containing a PEG2 spacer and an azide group. It enables capture of biomolecules via biotin-avidin interactions and controlled release upon UV irradiation, and is compatible with copper-catalyzed and strain-promoted azide-alkyne click chemistry.
- Photocleavable biotin enables UV-triggered release.
- Azide functional group for CuAAC and SPAAC conjugation.
- PEG2 spacer improves solubility and reduces steric hindrance.
- High purity suitable for biochemical applications.
- Available in small milligram-scale packages for research use.
Medchemexpress LLC m-PEG6-NHS ester | 1449390-12-8 | ≥97.0% | 421.44 g·mol⁻¹ | C18H31NO10 | 50 MG
m-PEG6-NHS ester is a non-cleavable 6-unit polyethylene glycol (PEG) linker terminating in an activated N-hydroxysuccinimide (NHS) ester; it is used for amide coupling to amines in the synthesis of antibody-drug conjugates and PROTACs.
- Purity: ≥97.0%.
- Molecular weight: 421.44 g·mol⁻¹.
- Chemical formula: C18H31NO10.
- CAS number: 1449390-12-8.
- Form: liquid, colorless to light yellow; density ~1.21 g/cm³.
- Storage: pure form -20 °C (3 years) or 4 °C (2 years); in solvent -80 °C (6 months) or -20 °C (1 month).
- Applications: non-cleavable PEG6 linker for ADC synthesis; PEG/alkyl/ether-based PROTAC linker.
- Packaging: commonly available in 100 MG, 250 MG, 1 G, and 5 G; larger quantities available by quote; a 50 MG pack is indicated in supplier data but on the manufacturer page.
Medchemexpress LLC Heneicosaoxa PEG diacid bis(2,5-dioxo-1-pyrrolidinyl) ester | 2221948-98-5 | MFCD21363289 | 98.0% | 1237.34 g/mol | C54H96N2O29 | 100 MG
Bis-PEG21-NHS ester is a bifunctional polyethylene glycol (PEG)-based N-hydroxysuccinimide (NHS) ester linker used for amine conjugation in the synthesis of PROTACs and antibody-drug conjugates. It provides hydrophilicity and spacing between conjugated moieties.
- Bifunctional NHS ester for amine conjugation.
- PEG21 spacer provides hydrophilicity and flexibility.
- Suitable for PROTAC and ADC linker assembly.
- High purity: 98.0%.
- Molecular weight ~1237.34 g/mol.
- Solid powder; store powder at -20°C; in solvent store at -80°C (6 months) or -20°C (1 month).
- Available in lab-scale quantities such as 100 MG.
Medchemexpress LLC Biotin pentafluorophenyl ester | 120550-35-8 | 97.0% | 100 MG
Biotin pentafluorophenyl ester is a biotinylated activated ester used to introduce a biotin affinity tag through reaction with nucleophiles. It serves as an alkyl/ether-based PROTAC linker and reagent for biotinylation in chemical biology and proteomics workflows.
- Activated pentafluorophenyl (PFP) ester for efficient coupling to amines and alcohols.
- Introduces a biotin handle for streptavidin-based capture and detection.
- Useful in PROTAC linker assembly, probe synthesis, and affinity enrichment.
- Supplied as a white to off-white solid with molecular weight 410.36 g·mol⁻¹.
Medchemexpress LLC CD79B Human Biotin 100ug
Recombinant human CD79B (extracellular residues Ala29-Asp159) produced in HEK293 cells and enzymatically biotinylated via an Avi tag. The construct includes a C-terminal His-Avi fusion, is >95% pure, and migrates ~35-45 kDa on SDS-PAGE due to glycosylation. Supplied with storage and reconstitution guidance for use in immobilization and binding assays.
- Site-specific biotinylation for consistent immobilization.
- C-terminal His-Avi tag for purification and controlled biotinylation.
- Mammalian expression preserves native glycosylation and folding.
- High purity suitable for ELISA, SPR/BLI, and flow cytometry.
- Storage and reconstitution recommendations to maintain activity.